BIX-01294

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抑制剂描述：

产品名称：BIX-01294

产品别名：N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine

英文别名：BIX 01294;BIX01294;BIX-01294

靶点：G9a

CAS：935693-62-2

纯度：＞98%

外观：Off-white solid

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -80℃ for six months.

描述：

BIX01294 is an inhibitor of G9a histone methyltransferase with IC50 of 2.7 μM.

溶解性：H2O : 14.29 mg/mL (29.13 mM; Need ultrasonic)

体外研究：

BIX-01294 (4.1 μM) treatment of G9anull ES cells results in a further reduction in H3K9me2 levels. BIX-01294 reduces H3K9me2 at several G9a target genes. BIX-01294 (5 µM) reduces levels of global H3K9 methylation in pronuclear- and 2-cell-stage embryos. Embryos transiently exposed to BIX-01294 have a reduced ability to establish pregnancy. BIX-01294 (1 µg/mL) causes reduction in the BrdU incorporation of fetal PASMCs. BIX-01294 treatment decreases the PASMCs migration induced by PDGF.

体内研究：

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