(S)-M8-SPy

1)【【咨询订购 400-811-9081 13681619662】】货号：M755300; 2) 化学名称： (S)-M8-SPy; 3) CAS No.: 1192364-56-9; 4) 分子式: C31H52N6O7S2; 5) 分子量: 684.91; 6) 包装: 10mg / ; 7) 外观: ; 8) 应用 A new lanthanide chelating tag (M8) for paramagnetic labeling of biomols. is presented, which is based on an eight-fold, stereoselectively methyl-substituted DOTA that can be covalently linked to the host molecule by a single disulfide bond. The steric overcrowding of the DOTA scaffold leads to an extremely rigid, kinetically and chemically inert lanthanide chelator. Due to its exceptionally high stability and lanthanide affinity M8 can be used under extreme chemical or physical conditions, such as those applied for protein denaturation, or when it is undesirable that buffer or protein react with excess lanthanide ions.; 9) 别名 (α1S,α4S,α7S,2S,5S,8S,11S)-α1,α4,α7,2,5,8,11-Heptamethyl-10-[(1S)-1-methyl-2-oxo-2-[[2-(2-pyridinyldithio)ethyl]amino]ethyl]-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic Acid; ; 10) 溶解性: ; 11) 储存条件: ; 12) 参考文献: Ebright, Y., et al.: Biochemistry, 31, 10664 (1992), Gaponenko, V., et al.: Biochemistry, 2000, 39, 15217 (2000), Su, X., et al.: ChemBioChem., 7, 1599 (2006),