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网站主页 RECOMBINANT HUMAN EGFR/HER1/ERBB1 Recombinant Human EGFR/HER1/ERBB1
  • Recombinant Human  EGFR/HER1/ERBB1

Recombinant Human EGFR/HER1/ERBB1

Recombinant Human EGFR/HER1/ERBB1
26880.00 1mg 起订
1680.00 10ug 起订
17240.00 500ug 起订
4920.00 50ug 起订
北京 更新日期:2024-11-01

北京索莱宝科技有限公司

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联系人:索莱宝
电话:010-50973130拨打
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邮箱:3193328036@qq.com

产品详情:

中文名称:
Recombinant Human EGFR/HER1/ERBB1
英文名称:
Recombinant Human EGFR/HER1/ERBB1
Derived from:
Human cells
Endotoxin:
Less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.
Formulation:
Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
Purity:
Greater than 95% as determined by reducing SDS-PAGE.
产品编号:
P00176

Recombinant Human Epidermal Growth Factor Receptor is produced by our Mammalian expression system and the target gene encoding Leu25-Ser645 is expressed with a 6His tag at the C-terminus.

Reconstitution

Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in ddH2O.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Background

The EGFR subfamily of receptor tyrosine kinases is composed of EGFR, ErbB2, ErbB3 and ErbB4. The EGFR shares 43% - 44% aa sequence identity with the ECD of human EGFR subfamily. All these family members are type I transmembrane glycoproteins with an extracellular ligand binding domain. The extracellular ligand binding domain is containing two cysteine-rich domains separated by a spacer region and a cytoplasmic domain containing a membrane-proximal tyrosine kinase domain. Ligand binding could induce EGFR homodimerization and heterodimerization with ErbB2, resulting in cell signaling, heterodimerization tyrosine phosphorylation and kinase activation. It can bind EGF, amphiregulin, TGF-alpha, betacellulin, epiregulin, HB-EGF, epigen, and so on. Its signaling regulates multiple biological functions including cell proliferation, differentiation, motility, and apoptosis. EGFR can also be recruited to form heterodimers with the ligand-activated ErbB3 or ErbB4. EGFR is overexpressed in different tumors. Several anti-cancer drugs use EGFR as target.

Storage

Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months

Known as

Epidermal growth factor receptor;Proto-oncogene c-ErbB-1;Receptor tyrosine-protein kinase erbB-1; EGFR;ERBB; ERBB1; HER1
Recombinant Human EGFR/HER1/ERBB1;细胞生物学

公司简介

北京索莱宝科技有限公司是一家集研发、生产、销售、服务于一体的高科技生物企业。技术推广;技术转让;技术咨询;技术服务;生物试剂技术开发;销售生物试剂盒、实验室专用化学试剂、实验室专用设备、办公用品、化工产品(不含危险化学品)、计算机软件及辅助设备;货物进出口、技术进出口、代理进出口;委托加工生产生物制品、生化制品、化工产品(不含危险化学品);生产生物试剂盒;批发第一类医疗器械、第二类医疗器械;批发第三类医疗器械。

成立日期 (21年)
注册资本 1000万元
员工人数 50-100人
年营业额 ¥ 500万-1000万
经营模式 贸易,工厂,试剂
主营行业 分析化学,生物化工,化学试剂,医药原料,仪器耗材

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