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网站主页 RECOMBINANT HUMAN CYTOTOXIC T-LYMPHOCYTE PROTEIN 4/CTLA4/CD152(FC FUSION) Recombinant Human Cytotoxic T-lymphocyte protein 4/CTLA4/CD152(Fc fusion)
  • Recombinant Human  Cytotoxic T-lymphocyte protein 4/CTLA4/CD152(Fc fusion)

Recombinant Human Cytotoxic T-lymphocyte protein 4/CTLA4/CD152(Fc fusion)

Recombinant Human Cytotoxic T-lymphocyte protein 4/CTLA4/CD152(Fc fusion)
330.00 10ug 起订
890.00 50ug 起订
8060.00 1mg 起订
5040.00 500ug 起订
北京 更新日期:2024-12-25

北京索莱宝科技有限公司

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产品详情:

中文名称:
Recombinant Human Cytotoxic T-lymphocyte protein 4/CTLA4/CD152(Fc fusion)
英文名称:
Recombinant Human Cytotoxic T-lymphocyte protein 4/CTLA4/CD152(Fc fusion)
Derived from:
Human cells
Endotoxin:
Less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.
Formulation:
Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
Known as:
Cytotoxic T-lymphocyte protein 4;Cytotoxic T-lymphocyte-associated antigen 4;CTLA4;CD152
Purity:
Greater than 95% as determined by reducing SDS-PAGE.
产品编号:
P00173

Recombinant Human Cytotoxic T-lymphocyte protein 4 is produced by our Mammalian expression system and the target gene encoding Lys36-Asp161 is expressed with a Fc tag at the C-terminus.

Background

Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily. Human or mouse CTLA4 cDNA encodes 223 amino acids (aa) including a 35 aa signal sequence, a 126 aa extracellular domain (ECD) with one Ig-like V-type domain, a 21 aa transmembrane (TM) sequence, and a 41 aa cytoplasmic sequence.It is widely expressed with highest levels in lymphoid tissues. CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T Cells and may play an important role in their functions. Tcell activation through the Tcell receptor and CD28 leads to increased expression of CTLA4.

Reconstitution

Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in ddH2O.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Storage

Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months
Recombinant Human Cytotoxic T-lymphocyte protein 4/CTLA4/CD152(Fc fusion);细胞生物学

公司简介

北京索莱宝科技有限公司是一家集研发、生产、销售、服务于一体的高科技生物企业。技术推广;技术转让;技术咨询;技术服务;生物试剂技术开发;销售生物试剂盒、实验室专用化学试剂、实验室专用设备、办公用品、化工产品(不含危险化学品)、计算机软件及辅助设备;货物进出口、技术进出口、代理进出口;委托加工生产生物制品、生化制品、化工产品(不含危险化学品);生产生物试剂盒;批发第一类医疗器械、第二类医疗器械;批发第三类医疗器械。

成立日期 (21年)
注册资本 1000万元
员工人数 50-100人
年营业额 ¥ 500万-1000万
经营模式 贸易,工厂,试剂
主营行业 分析化学,生物化工,化学试剂,医药原料,仪器耗材

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