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  • Anti-SH2D1B Polyclonal Antibody

Anti-SH2D1B Polyclonal Antibody

Anti-SH2D1B Polyclonal Antibody
960.00 50ul 起订
1600.00 100ul 起订
北京 更新日期:2024-07-22

北京索莱宝科技有限公司

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联系人:索莱宝
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产品详情:

中文名称:
Anti-SH2D1B Polyclonal Antibody
英文名称:
Anti-SH2D1B Polyclonal Antibody
Subcellular Locations:
Cytoplasm
Swiss Prot:
O14796
保存:
Store at -20°C. Avoid freeze / thaw cycles.
别名:
EAT2;SH2 domain containing 1B
产品编号:
K107304P
储存液:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法:
Affinity purification
蛋白分子量:
15/9kDa
交叉反应:
Human
克隆类型:
Polyclonal Antibody
免疫原:
A synthetic peptide of human SH2D1B
宿主:
Rabbit
稀释比例:
WB 1:1000-3000.
亚型:
IgG
应用:
WB
英文名称:
Anti-SH2D1B Polyclonal Antibody

背景资料

Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as CD84, SLAMF1, LY9 and CD244 (PubMed:11689425). In SLAM signaling seems to cooperate with SH2D1A/SAP. Plays a role in regulation of effector functions of natural killer (NK) cells by controlling signal transduction through CD244/2B4 without effecting its tyrosine phosphorylation; downstream signaling involves PLCG1 and ERK activation . Activation of SLAMF7-mediated NK cell function does not effect receptor tyrosine phosphorylation but distal signaling . In the context of NK cell-mediated cytotoxicity does not enhance conjugate formation with target cells but stimulates polarization of the microtubule-organizing center and cytotoxic granules toward the NK cell synapse . Negatively regulates CD40-induced cytokine production in dendritic cells downstream of SLAM family receptors probably by inducing activation of the PI3K pathway to inhibit p38 MAPK and JNK activation.
Anti-SH2D1B Polyclonal Antibody;抗体

公司简介

北京索莱宝科技有限公司是一家集研发、生产、销售、服务于一体的高科技生物企业。技术推广;技术转让;技术咨询;技术服务;生物试剂技术开发;销售生物试剂盒、实验室专用化学试剂、实验室专用设备、办公用品、化工产品(不含危险化学品)、计算机软件及辅助设备;货物进出口、技术进出口、代理进出口;委托加工生产生物制品、生化制品、化工产品(不含危险化学品);生产生物试剂盒;批发第一类医疗器械、第二类医疗器械;批发第三类医疗器械。

成立日期 (20年)
注册资本 1000万元
员工人数 50-100人
年营业额 ¥ 500万-1000万
经营模式 贸易,工厂,试剂
主营行业 分析化学,生物化工,化学试剂,医药原料,仪器耗材

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