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  • Anti-MGMT Polyclonal Antibody

Anti-MGMT Polyclonal Antibody

Anti-MGMT Polyclonal Antibody
1600.00 100ul 起订
960.00 50ul 起订
北京 更新日期:2024-07-26

北京索莱宝科技有限公司

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联系人:索莱宝
电话:010-50973130拨打
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邮箱:3193328036@qq.com

产品详情:

中文名称:
Anti-MGMT Polyclonal Antibody
英文名称:
Anti-MGMT Polyclonal Antibody
Gene ID:
4255
Public Immunogen Range:
Recombinant protein of human MGMT
Subcellular Locations:
Nucleus
Swiss Prot:
P16455
保存:
Store at -20°C. Avoid freeze / thaw cycles.
别名:
6-O-methylguanine-DNA methyltransferase
产品编号:
K006793P
储存液:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法:
Affinity purification
蛋白分子量:
22kDa
交叉反应:
Human
克隆类型:
Polyclonal Antibody
免疫原:
Recombinant protein of human MGMT
宿主:
Rabbit
稀释比例:
WB 1:200-1000.
性状:
液体
亚型:
IgG
应用:
WB
英文名称:
Anti-MGMT Polyclonal Antibody

背景资料

MGMT (O6-methylguanine-DNA methyltransferase) is transcriptionally activated in response to DNA damage and functions to repair mutagenic and cytotoxic O6-alkylguanine lesions caused by carcinogens or cytostatic drugs. MGMT induction by ionising radiation does not occur in p53-deficient mice, suggesting that MGMT induction may require p53. Similarly, MGMT mRNA and protein were shown to be inducible by ionising radiation, only in cell lines that express functional p53, and not in cell lines that do not express wild type p53. In contrast, high MGMT activity was associated with the presence of mutant p53, in a study of oral cancer cell lines. Similarly, MGMT activity was significantly lower in ovarian tumors with wildtype p53 than in tumors with mutant p53, supporting the view that wildtype p53 down-regulates the basal MGMT promoter.
Anti-MGMT Polyclonal Antibody;抗体

公司简介

北京索莱宝科技有限公司是一家集研发、生产、销售、服务于一体的高科技生物企业。技术推广;技术转让;技术咨询;技术服务;生物试剂技术开发;销售生物试剂盒、实验室专用化学试剂、实验室专用设备、办公用品、化工产品(不含危险化学品)、计算机软件及辅助设备;货物进出口、技术进出口、代理进出口;委托加工生产生物制品、生化制品、化工产品(不含危险化学品);生产生物试剂盒;批发第一类医疗器械、第二类医疗器械;批发第三类医疗器械。

成立日期 (20年)
注册资本 1000万元
员工人数 50-100人
年营业额 ¥ 500万-1000万
经营模式 贸易,工厂,试剂
主营行业 分析化学,生物化工,化学试剂,医药原料,仪器耗材

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