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  • Anti-LAG3 Polyclonal Antibody

Anti-LAG3 Polyclonal Antibody

Anti-LAG3 Polyclonal Antibody
1600.00 100ul 起订
960.00 50ul 起订
北京 更新日期:2024-11-08

北京索莱宝科技有限公司

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产品详情:

中文名称:
Anti-LAG3 Polyclonal Antibody
英文名称:
Anti-LAG3 Polyclonal Antibody
Gene ID:
3902
Subcellular Locations:
Membrane Single-pass type I membrane protein Secreted
Swiss Prot:
P18627
保存:
Store at -20°C. Avoid freeze / thaw cycles.
别名:
CD223;FDC;lymphocyte activating 3
产品编号:
K008858P
产品类型:
一抗
储存液:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法:
Affinity purification
蛋白分子量:
57/39kDa
交叉反应:
Human
克隆类型:
Polyclonal Antibody
免疫原:
A synthetic peptide of human LAG3
宿主:
Rabbit
稀释比例:
WB 1:500-2000.
亚型:
IgG
应用:
WB
英文名称:
Anti-LAG3 Polyclonal Antibody

背景资料

Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells . Delivers inhibitory signals upon binding to ligands, such as FGL1 (By similarity). FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function (By similarity). Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity). May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/PD-1 (By similarity). Negatively regulates the proliferation, activation, effector function and homeostasis of both CD8+ and CD4+ T-cells . Also mediates immune tolerance: constitutively expressed on a subset of regulatory T-cells (Tregs) and contributes to their suppressive function (By similarity). Also acts as a negative regulator of plasmacytoid dendritic cell (pDCs) activation (By similarity). Binds MHC class II (MHC-II); the precise role of MHC-II-binding is however unclear.
Anti-LAG3 Polyclonal Antibody;抗体

公司简介

北京索莱宝科技有限公司是一家集研发、生产、销售、服务于一体的高科技生物企业。技术推广;技术转让;技术咨询;技术服务;生物试剂技术开发;销售生物试剂盒、实验室专用化学试剂、实验室专用设备、办公用品、化工产品(不含危险化学品)、计算机软件及辅助设备;货物进出口、技术进出口、代理进出口;委托加工生产生物制品、生化制品、化工产品(不含危险化学品);生产生物试剂盒;批发第一类医疗器械、第二类医疗器械;批发第三类医疗器械。

成立日期 (21年)
注册资本 1000万元
员工人数 50-100人
年营业额 ¥ 500万-1000万
经营模式 贸易,工厂,试剂
主营行业 分析化学,生物化工,化学试剂,医药原料,仪器耗材

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