[Product name]: Toosendanin
[Synonym]:
[Plant Source]: CORTEX MELIAE
[Chemical name]: 1-isothiocyanato-4-(methyl-sulfinyl) butane
[Structural formula]: C30H38O11
[CAS Reg]: 79304-40-8
[Molecular weight]: 574.63
[Specification]: Toosendanin assay: 1.5%, 25%, 98% (HPLC), or custom-made according to the customer request
[Main functions]:
Toosendanin (TSN), a tetranortriterpenoid compound from the plant Melia toosendan, has been reported to protect rats and non-human primates from the lethal actions of botulinum neurotoxin A (BoNT/A). TSN was tested in isolated mouse phrenic nerve-hemidiaphragm preparations against BoNT serotypes A, B and E. When added prior to toxin, TSN was found to delay the onset of muscle paralysis with all 3 BoNT serotypes. TSN had little or no effect on BoNT-induced muscle paralysis when applied 30 min after BoNT. It is suggested that the antagonist activity of TSN may result from inhibition of BoNT translocation.
