基本信息 产品图片 产品描述 供应商联系方式 同类产品

Anti-CDKN2A Polyclonal Antibody

基本信息 产品图片 产品描述 供应商联系方式 同类产品

基本信息:

  • 发布时间: 2020-08-10
  • 产品名称: Anti-CDKN2A Polyclonal Antibody
  • 产品英文名称: Anti-CDKN2A Polyclonal Antibody
  • CAS号: 
  • 产品包装: 50ul
  • 产品价格: 960.00ul
  • 有效期: 
  • 品牌: 
  • 产地: 
  • 保存条件: 
  • 纯度规格: 
  • 产品类别: 

产品图片:

Anti-CDKN2A Polyclonal Antibody

产品描述:

背景资料

This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.

别名

CDKN2A;ARF;CDK4I;CDKN2;CMM2;INK4;INK4A;MLM;MTS-1;MTS1;P14;P16;P16-INK4A;P16INK4;P16INK4A;P19;P19ARF;TP16;cyclin-dependent kinase inhibitor 2A
Anti-CDKN2A Polyclonal Antibody;抗体
  • 供应商联系方式:
  • 联系人 马金成
  • 公司名称 北京索莱宝科技有限公司
  • 电话 010-56371250
  • 手机 15930773779
  • 传真 
  • 邮箱 2748554845@qq.com
  • 地址 联东U谷景盛南四街85A三层
  • 公司简介:
  • 北京索莱宝科技有限公司是一家集研发、生产、销售、服务于一体的高科技生物企业。技术推广;技术转让;技术咨询;技术服务;生物试剂技术开发;销售生物试剂盒、实验室专用化学试剂、实验室专用设备、办公用品、化工产品(不含危险化学品)、计算机软件及辅助设备;货物进出口、技术进出口、代理进出口;委托加工生产生物制品、生化制品、化工产品(不含危险化学品);生产生物试剂盒;批发第一类医疗器械、第二类医疗器械;批发第三类医疗器械。
Anti-CDKN2A Polyclonal Antibody生产厂家及价格: