Bcl-xL Antibody

ProSci Incorporated 於1998年成立于世界生物城之一的美国加州圣地亚哥市，是世界最早和的细胞凋亡抗体生产厂家和供应商，公司现拥有17000多种单、多克隆抗体，产品涵盖了细胞凋亡、信号转导、免疫、肿瘤、细胞生物、神经生物、传染病等领域。ProSci公司的抗体大都经免疫亲和层析纯化，经过了严格的验证测试和质量控制，具有高纯度、高亲和力、特异性强等特点，可用于免疫印迹（Western blot），免疫组织化学（IHC），免疫细胞化学（ICC），酶联免疫吸附实验（ELISA）和细胞流式分析（FACS）等方面。ProSci的抗体产品已应用在1281篇SCI论文中，其中2011年的有228篇，ProSci的经销商和客户都对ProSci的产品质量和服务十分满意，ProSci公司在2003、2007、2010年度都被《Nature》评为免疫学试剂推荐品牌，抗体研发、生产和服务优秀供应商。
Bcl-xL Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Bcl-xL is a member of the Bcl-2 family of proteins that are critical regulators of apoptosis. These can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bcl-xL is an anti-apoptotic mitochondrial protein related to Bcl-w and the major transcript of the bcl-x gene. Its high expression in tumors is correlated with advanced disease and poor prognosis. Bcl-xL expression level increases in response to several stimuli such as ionizing radiation and treatment with chemotherapeutic agents.