CaMKIV Antibody

品牌:CST，产品名称：CaMKIV Antibody #4032
英文名称：CaMKIV Antibody
Product name：CaMKIV Antibody #4032
Source：Rabbit
Sensitivity：Endogenous
MW(kDa)：58, 60: human. 61, 63: rat and mouse.
Reactivity：H,M,R
Applications：WB , IP ,
Purification： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide around amino acid 282-300 of human CaMKIV. Antibodies are purified by protein A and peptide affinity chromatography.
Background： CaMKIV is an important member of calcium/calmodulin-activated kinases. CaMKIV signaling has been related to long-term neural potentiation and memory (1,2), as well as T-cell receptor signaling (3). CaMKIV has catalytic and regulatory domains. The Ca2+/calmodulin-dependent CaMKK phosphorylates CaMKIV, releasing the autoinhibitory effect and thus activating the kinase (4-6). The activated CaMKIV further autophosphorylates itself at Thr196 (or Thr200 in human) to render the kinase constitutively active (5). The threonine phosphorylation state of CaMKIV can be downregulated by PP2A dephosphorylation.

Entrez-Gene Id

814

Swiss-Prot Acc.

Q16566

Specificity / Sensitivity:

CaMKIV Antibody detects total levels of endogenous CaMKIV.

Species Reactivity:

Human, Mouse, Rat

Application	Dilutions
Western Blotting	1:1000
Immunoprecipitation	1:50

Storage:

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.