ACS 67

询价 1EA 起订

上海更新日期：2025-02-18

上海超研生物科技有限公司

非会员

联系人：超研

电话：13917350246拨打

手机：13917350246 拨打

邮箱：purchase@51chaoyan.com

产品详情:

英文名称：: ACS 67

保质期：: 2年

保存条件：: -20°C

数量：: 大量

CAS号：: 1088434-86-9

供应商：: 超研生物

规格：: 1mg/5mg/10mg/25mg

货号：: 13619

Description

Latanoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug for the treatment of glaucoma.¹ Latanoprost is an isopropyl ester, a prodrug form which is converted to latanoprost (free acid) by endogenous esterase enzymes. The free acid form is 200 times more potent than latanoprost as an FP receptor ligand for the human recombinant FP receptor.² ACS 67 is an analog of latanoprost (free acid) that contains a hydrogen sulfide releasing component conjugated to the latanoprost carboxyl group.³ In glaucomatous pigmented rabbits, ACS 67 reduced intra-ocular pressure (IOP) more rapidly and to a greater extent than latanoprost (15 versus 25.5 mm Hg at four hours) at a dose of 0.005% for each compound.³ ACS 67 also increased the levels of reduced glutathione and cGMP in the aqueous humor of glaucomatous pigmented rabbits better than latanoprost.³

1 Stjernschantz, J., and Resul, B. Phenyl substituted prostaglandin analogs for glaucoma treatment. Drugs Future 17 691-704 (1992).

2 Abramovitz, M., Adam, M., Boie, Y., et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta 1483 285-293 (2000).

3 Perrino, E., Uliva, C., Lanzi, C., et al. New prostaglandin derivative for glaucoma treatment. Bioorg Med Chem Lett 19 1639-1642 (2009).

Formal Name	7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl ester, 5Z-heptenoic acid
CAS Number	1088434-86-9
Molecular Formula	C₃₂H₃₈O₅S₃
Formula Weight	598.8
Formulation	A crystalline solid
Purity	≥95%
Stability	2 years
Storage	-20°C

温馨提示：不可用于临床治疗。

ACS 67;试剂

公司简介

上海超研生物科技有限公司是一家专注于生命科学和生物技术领域的高新技术企业，专业从事科研机构及生产企业所需要的科研试剂、耗材、仪器以及技术服务。产品涉及分子生物学、细胞生物学、遗传学、免疫学、生物化学、蛋白质学等相关产品。目前代理了十多家欧美著名生物技术公司的产品。其中主要代理及经销品牌有：Applygen、Abcam、Bioworld、Biomed、Cayman、Corning、CST、Megazyme、Millipore、PeproTech、Phytotech、Prospec、ProteintechGroup、Roche、Sigma-Aldrich、Santa Cruz等。同时为了更好更快捷的为国内广大科研用户提供服务，公司存备了大量现货（常用的生化试剂和耗材），配合优秀的销售队伍以及专业的技术支

成立日期	(17年)
注册资本	50.000000万人民币
员工人数	50-100人
年营业额	￥ 300万-500万
经营模式	贸易,工厂,试剂,定制,服务
主营行业	生化试剂,抗体,蛋白组学,分子生物学