(R,R)-Formoterol

产品说明

β2-选择性肾上腺素能激动剂

该产品包含在以下化合物库中:

质量控制

• 纯度 = 98.00%

化学性质

CAS号	67346-49-0
别名	(-)-Formoterol;Arformoterol;Formoterol
分子式	C19H24N2O4	分子量	344.4
溶解性	25℃: DMSO	储存条件	Store at -20°

 

实验操作

细胞实验[2]：
细胞系
溶解方法
反应时间
应用
动物实验[3]：
动物模型
剂量
注意事项
References:

产品描述

Description:IC50 Value: N/AFormoterol is a novel highly β2-selective adrenergic agonist and holds promise as a β2-agonist that could impart selective beneficial metabolic effects.in vitro: Formoterol restored Dex sensitivity by inhibiting phosphorylation of GR-Ser226 and JNK1[1]. Formoterol (FM), but not SM, partially inhibited H(2) O(2) -induced PI3Kδ-dependent (PKB) phosphorylation. H(2) O(2) decreased SM-induced cAMP production in U937 cells, but did not significantly affect the response to FM [3].in vivo: Mice exposed to formoterol for 24 or 72 h exhibited increases in kidney and heart mtDNA copy number, peroxisome proliferator-activated receptor γ coactivator 1α, and multiple genes involved in the mitochondrial electron transport chain (F0 subunit 6 of transmembrane F-type ATP synthase, NADH dehydrogenase subunit 1, NADH dehydrogenase subunit 6, and NADH dehydrogenase [ubiquinone] 1β subcomplex subunit 8) [2]. Formoterol and ritodrine inhibited the amplitude and frequency of rat uterine contraction, with IC50 values of 3.8 x 10(-10) and 4.7 x 10(-7) M, respectively [4].Clinical trial: N/A