产品编号 |
产品名称 |
产品包装 |
产品价格 |
P5399-1mg |
Recombinant Human 4-1BB Receptor/TNFRSF9 |
1mg |
15444.00元 |
Species
|
Gene ID
|
Accession
|
Source
|
Length
|
MW
|
Tag
|
Human
|
3604
|
Q07011
|
E. coli
|
166aa
|
17.7kDa
|
-
|
About this Antibody
|
Name
|
Recombinant Human 4-1BB Receptor/TNFRSF9 (Recombinant Human 4-1BB Receptor; rHu4-1BB Receptor);重组人4-1BB受体/TNFRSF9
|
Synonyms
|
CD137; ILA; TNFRSF9; 4-1BB; 4-1BB ligand receptor; CD137 antigen; CD137MGC2172; CDw137; FLJ43501; ILAhomolog of mouse 4-1BB; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63; receptor protein 4-1BB; T cell antigen ILA; T-cell antigen 4-1BB homolog; T-cell antigen ILA; tumor necrosis factor receptor superfamily member 9; tumor necrosis factor receptor superfamily, member 9
|
Purity
|
>97% by SDS-PAGE and HPLC analyses.
|
Biological Activity
|
Fully biologically active when compared to standard. The biological activity is determined by its inhibitory effect of IL-8 production using human peripheral blood mononuclear cells. About 90% of inibition was seen using a concentration of 1μg for both 4-1BB Ligand and 4-1BB Receptor.
|
Physical Appearance
|
Sterile Filtered White lyophilized (freeze-dried) powder.
|
Formulation
|
Lyophilized from a 0.2μm filtered concentrated solution in 10mM PB, pH8.0, 150mM NaCl.
|
Endotoxin
|
Less than 1EU/μg of rHu4-1BB Receptor as determined by LAL method.
|
Reconstitution
|
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤-20℃. Further dilutions should be made in appropriate buffered solutions.
|
Category
|
Cytokine
|
Background
|
4-1BB receptor, also named TNFRSF9 is a member of the TNF superfamily of receptors. It is mainly expressed on the surface of a variety of T cells, but also found in B cells, monocytes, and various transformed cell lines. 4-1BB receptor binds to 4-1BBL, and they co-stimulate activity for activated T cells. Signaling by 4-1BB Receptor has been implicated in the antigen-presentation process and generation of cytotoxic T cells. Crosslinking of 4-1BB Receptor enhances T cell proliferation, IL-2 secretion survival and cytolytic activity. Further, it can enhance immune activity to eliminate tumors in mice.
|
Amino Acid Sequence
|
ERTRSLQDPC SNCPAGTFCD NNRNQICSPC PPNSFSSAGG QRTCDICRQC KGVFRTRKEC SSTSNAECDC TPGFHCLGAG CSMCEQDCKQ GQELTKKGCK DCCFGTFNDQ KRGICRPWTN CSLDGKSVLV NGTKERDVVC GPSPADLSPG ASSVTPPAPA REPGHS
|
包装清单:
产品编号
|
产品名称
|
包装
|
P5399-5μg
|
Recombinant Human 4-1BB Receptor/TNFRSF9
|
5μg
|
P5399-20μg
|
Recombinant Human 4-1BB Receptor/TNFRSF9
|
20μg
|
P5399-100μg
|
Recombinant Human 4-1BB Receptor/TNFRSF9
|
100μg
|
P5399-1mg
|
Recombinant Human 4-1BB Receptor/TNFRSF9
|
1mg
|
-
|
说明书
|
1份
|
保存条件:
-20℃或更低温度保存,至少一年有效。由于蛋白的每次冻融均会引起部分失活,所以首次配制成相应浓度的储存液后(请根据产品简介中Reconstitution一栏的信息配制储存液),须分装后-20℃或更低温度冻存,以避免反复冻融。
注意事项:
由于有些塑料管壁对某些蛋白有较强的吸附作用,溶液中的蛋白很容易粘附在管壁上,并且粘附后的蛋白很难与管壁分离。而载体蛋白(Carrier protein,如0.1% BSA等)的主要作用是预先封闭塑料管壁上的蛋白结合位点,使细胞因子或重组蛋白不会粘附于管壁。所以一定要使用产品简介中Reconstitution一栏的信息配制储存液。
本产品仅限于专业人员的科学研究用,不得用于临床诊断或治疗,不得用于食品或药品,不得存放于普通住宅内。
为了您的安全和健康,请穿实验服并戴一次性手套操作。