Recombinant Murine Fractalkine/CX3CL1

Species

Gene ID

Accession

Source

Length

MW

Tag

Mouse

20312

O35188

E. coli

76aa

8.7kDa

－

About this Antibody

Name

Recombinant Murine Fractalkine/CX3CL1 (Recombinant Murine Fractalkine/CX3CL1; rMuFractalkine/CX3CL1)；Recombinant Mouse Fractalkine/CX3CL1 ; 重组小鼠膜结合型趋化因子/CX3CL1

Synonyms

FKN; Fractalkine; Neurotactin; ABCD-3; C3Xkine; chemokine (C-X3-C motif) ligand 1; CX3C membrane-anchored chemokine; CXC3; CXC3C; FKN; fractalkine; Neurotactin; neurotactin; neurotactin); NTNsmall inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine; NTTSmall-inducible cytokine D1; SCYD1C-X3-C motif chemokine 1; small inducible cytokine subfamily D (Cys-X3-Cys), member-1

Purity

>97% by SDS-PAGE and HPLC analyses.

Biological Activity

Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human peripheral blood lymphocytes (PBL) is less than 0.5μg/ml, corresponding to a specific activity of >2000IU/mg.

Physical Appearance

Sterile Filtered White lyophilized (freeze-dried) powder.

Formulation

Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH7.4.

Endotoxin

Less than 0.1EU/μg of rMuFractalkine/CX3CL1 as determined by LAL method.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤-20℃. Further dilutions should be made in appropriate buffered solutions.

Category

Chemokines

Background

CX3CL1 recently identified through bioinformatics is the only known member of the CX3C chemokine family and it is also commonly known under the names fractalkine (in humans) and neurotactin (in mice). Unlike other known chemokines, CX3CL1 is a type 1 membrane protein containing a chemokine domain tethered on a long mucinlike talk. The soluble form of CX3CL1 is chemotactic for T-cells and monocytes, but not for neutrophils. CX3CL1 may play a role in regulating leukocyte adhesion and migration processes at the endothelium. Mouse CX3CL1 shares 85% and 78%a.a. sequence identity with rat and human CX3CL1, respectively, within the chemokine domain, but lower sequence identity within other domains.

Amino Acid Sequence

QHLGMTKCEI MCGKMTSRIP VALLIRYQLN QESCGKRAIV LETTQHRRFC ADPKEKWVQD AMKHLDHQAA ALTKNG

产品编号

产品名称

包装

P6767-5μg

Recombinant Murine Fractalkine/CX3CL1

5μg

P6767-20μg

Recombinant Murine Fractalkine/CX3CL1

20μg

P6767-100μg

Recombinant Murine Fractalkine/CX3CL1

100μg

P6767-1mg

Recombinant Murine Fractalkine/CX3CL1

1mg

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说明书

1份