Recombinant Murine IFN-λ2/IL-28A

Species

Gene ID

Accession

Source

Length

MW

Tag

Mouse

330496

Q4VK74

E. coli

174aa

19.7kDa

－

About this Antibody

Name

Recombinant Murine IFN-λ2/IL-28A (Recombinant Murine Interferon-λ2/Interleukin-28A; rMuIFN-λ2/IL-28A)；Recombinant Mouse IFN-λ2/IL-28A ; 重组小鼠干扰素λ2/白细胞介素28A

Synonyms

IFN-lambda 2; interleukin-28A; IL28A; IL-28A; interferon, lambda 2

Purity

>95% by SDS-PAGE and HPLC analyses.

Biological Activity

Fully biologically active when compared to standard. The ED50 as determined by an anti-viral assay using human HepG2 cells infected with encephalomyocarditis is less than 3ng/ml, corresponding to a specific activity of >3.3×10⁵IU/mg.

Physical Appearance

Sterile Filtered lyophilized (freeze-dried) liquid-like powder.

Formulation

Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH7.4, with 5% trehalose.

Endotoxin

Less than 0.1EU/μg of rMuIFN-λ2/IL-28A as determined by LAL method.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤-20℃. Further dilutions should be made in appropriate buffered solutions.

Category

Cytokine

Background

Interferon lambda-2, as known as IL-28A, belongs to the lambda interferon family. IL-28A (IFN-λ2), IL-28B (IFN-λ3) and IL-29 (IFN-λ1) are type III interferons that are class II cytokine receptor ligands. These IFNs signal through a receptor complex consisting of IL10R2 (also called CRF2-4) and IFNLR1 (also called CRF2-12). Interferon lambda-2 displays potent antiviral activity and antitumor activity, so it plays a significant role in the antiviral immune defense in the intestinal epithelium. It also upregulate MHC class I antigen expression. Recombinant murine interferon lambda-2 contains 174 amino acids and it shares 81% and 66%a.a. sequence identity with rat and human IFN-λ2, respectively, and functions across species.

Amino Acid Sequence

DPVPRATRLP VEAKDCHIAQ FKSLSPKELQ AFKKAKDAIE KRLLEKDMRC SSHLISRAWD LKQLQVQERP KALQAEVALT LKVWENMTDS ALATILGQPL HTLSHIHSQL QTCTQLQATA EPKPPSRRLS RWLHRLQEAQ SKETPGCLED SVTSNLFRLL TRDLKCVASG DQCV

产品编号

产品名称

包装

P6141-5μg

Recombinant Murine IFN-λ2/IL-28A

5μg

P6141-20μg

Recombinant Murine IFN-λ2/IL-28A

20μg

P6141-100μg

Recombinant Murine IFN-λ2/IL-28A

100μg

P6141-1mg

Recombinant Murine IFN-λ2/IL-28A

1mg

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说明书

1份