Recombinant Rat CDNF

Species

Gene ID

Accession

Source

Length

MW

Tag

Rat

361276

P0C5I0

E. coli

163aa

18.8kDa

－

About this Antibody

Name

Recombinant Rat CDNF (Recombinant Rat Cerebral Dopamine Neurotrophic Factor; rRtCDNF)；重组大鼠大脑多巴胺神经营养因子

Synonyms

ARMETL1; arginine-rich, mutated in early stage tumors-like 1; ARMETL1; ARMET-like protein 1; cerebral dopamine neurotrophic factor; Conserved dopamine neurotrophic factor

Purity

>97% by SDS-PAGE and HPLC analyses.

Biological Activity

Fully biologically active when compared to standard. It is able to enhance neurite outgrowth of E16-E18 rat embryonic cortical neurons when immobilized at 5-25μg/ml on a nitrocellulose-coated microplate.

Physical Appearance

Sterile Filtered White lyophilized (freeze-dried) powder.

Formulation

Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH7.4.

Endotoxin

Less than 0.1EU/μg of rRtCDNF as determined by LAL method.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤-20℃. Further dilutions should be made in appropriate buffered solutions.

Category

Cytokine

Background

Cerebral dopamine neurotrophic factor (CDNF), also known as ARMET-like protein 1, is a protein encoded by the CDNF gene and it is widely expressed in neuronal and non-neuronal tissues. The cerebral dopamine neurotrophic factor (CDNF) also is a novel neurotrophic factor with strong trophic activity on dopaminergic neurons comparable to that of glial cell line-derived neurotrophic factor (GDNF). By research, CDNF prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons and it might be beneficial for the treatment of parkinson's disease. Recombinant rat CDNF contains 163 amino acid residues and it shares 83% and 87%a.a. sequence identity with human and murine CDNF.

Amino Acid Sequence

QGLEAGVRSR ADCEVCKEFL NRFYNSLLTR GIDFSVDTIE EELISFCADT KGKENRLCYY LGATKDSATK ILGEVTRPMS VHMPTVKICE KLKKMDSQIC ELKYEKKLDL ESVDLWKMRV AELKQILHSW GEECRACAEK HDYVNLIKEL APKYVETRPQ TEL

产品编号

产品名称

包装

P6420-5μg

Recombinant Rat CDNF

5μg

P6420-25μg

Recombinant Rat CDNF

25μg

P6420-100μg

Recombinant Rat CDNF

100μg

P6420-1mg

Recombinant Rat CDNF

1mg

-

说明书

1份