Recombinant Rhesus Macaque IL-13

Species

Gene ID

Accession

Source

Length

MW

Tag

Rhesus Macaque

574325

Q864V6

E. coli

114aa

12.6kDa

－

About this Antibody

Name

Recombinant Rhesus Macaque IL-13 (Recombinant Rhesus Macaque Interleukin-13; rRhIL-13)；重组恒河猴白细胞介素13

Synonyms

Interleukin-13; IL-13; IL13

Purity

>98% by SDS-PAGE and HPLC analyses.

Biological Activity

Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human TF-1 cells is less than 5ng/ml, corresponding to a specific activity of >2.0×10⁵IU/mg.

Physical Appearance

Sterile Filtered lyophilized (freeze-dried) liquid-like powder.

Formulation

Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH7.4, 3% trehalose.

Endotoxin

Less than 1EU/μg of rRhIL-13 as determined by LAL method.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤-20℃. Further dilutions should be made in appropriate buffered solutions.

Category

Cytokine

Background

Interleukin-13 (IL-13) is expressed by the IL13 gene and secreted by many cell types, especially T helper type 2 (Th2) cells. The high solution from of IL-13 reported to be a monomer with two internal disulfide bonds that contribute to a bundled four α-helix configuration. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1beta, TNF-alpha, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Mature rhesus IL-13 shares 94%, 58%, and 60% amino acid sequence identity with human, mouse and rat IL-13, respectively.

Amino Acid Sequence

SPSPVPRSTA LKELIEELVN ITQNQKAPLC NGSMVWSINL TAGVYCAALE SLINVSGCSA IEKTQRMLNG FCPHKVSAGQ FSSLRVRDTK IEVAQFVKDL LVHLKKLFRE GRFN

产品编号

产品名称

包装

P5862-2μg

Recombinant Rhesus Macaque IL-13

2μg

P5862-10μg

Recombinant Rhesus Macaque IL-13

10μg

P5862-100μg

Recombinant Rhesus Macaque IL-13

100μg

P5862-1mg

Recombinant Rhesus Macaque IL-13

1mg

-

说明书

1份