Recombinant Viral MIP-2

Species

Gene ID

Accession

Source

Length

MW

Tag

Viral

4961514

Q98157

E. coli

70aa

8kDa

－

About this Antibody

Name

Recombinant Viral MIP-2 (Recombinant Viral Macrophage Inflammatory Protein-2; rViMIP-2)；重组病毒巨噬细胞炎性蛋白2

Synonyms

Viral macrophage inflammatory protein 2; Viral macrophage inflammatory protein II; vMIP-II

Purity

>97% by SDS-PAGE and HPLC analyses.

Biological Activity

Fully biologically active when compared to standard. The specific activity is determined by the inhibitory effect on monocyte migration response to human MIP-1 alpha using a concentration range of 1.0μg-10.0μg/ml of viral MIP-2 will inhibit 25ng/ml of human MIP-1 alpha.

Physical Appearance

Sterile Filtered White lyophilized (freeze-dried) powder.

Formulation

Lyophilized from a 0.2μm filtered concentrated solution in 20mM PB, pH7.4, 150mM NaCl.

Endotoxin

Less than 1EU/μg of rViMIP-2 as determined by LAL method.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤-20℃. Further dilutions should be made in appropriate buffered solutions.

Category

Chemokines

Background

Viral MIP-2 is one of the three chemokine-like proteins expressed by the human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus, KSHV) and the other is ViMIP-1 and ViMIP-3. It shares 41% and 48% with human MIP-1α and ViMIP-1, respectively. ViMIP-2 has been shown to have antagonist activity towards a wide range of chemokine receptors and has functions of blocking infection by several different human immunodeficiency virus type 1 (HIV-1) strains. It may form part of the response to host defenses contributing to virus-induced neoplasia and may have relevance to KSHV and HIV-I interactions. Additionally, ViMIP-2 has been shown to activate and chemoattract human eosinphils.

Amino Acid Sequence

LGASWHRPDK CCLGYQKRPL PQVLLSSWYP TSQLCSKPGV IFLTKRGRQV CADKSKDWVK KLMQQLPVTA

产品编号

产品名称

包装

P6947-10μg

Recombinant Viral MIP-2

10μg

P6947-50μg

Recombinant Viral MIP-2

50μg

P6947-100μg

Recombinant Viral MIP-2

100μg

P6947-1mg

Recombinant Viral MIP-2

1mg

-

说明书

1份