Bisphosphoglycerate Mutase

Protein Name

Bisphosphoglycerate mutase

Protein Symbol

BPGM

Original Source

Expression System

GenBank Accession #

NM_001724.1

Uniprot Accession #

P07738

Description

2,3-diphosphoglycerate (2,3-DPG) is a small molecule found at high concentrations in red blood cells where it binds to and decreases the oxygen affinity of hemoglobin. This gene encodes a multifunctional enzyme that catalyzes 2,3-DPG synthesis via its synthetase activity, and 2,3-DPG degradation via its phosphatase activity. The enzyme also has phosphoglycerate phosphomutase activity. Deficiency of this enzyme increases the affinity of cells for oxygen. Mutations in this gene result in hemolytic anemia. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Application

WB, ELISA, IP, antibody production, protein array

Fusion tag

N-His

Peptide Length

274aa(including fusion tag)

Molecular Weight

31.9kDa(including fusion tag)

pI

6.9

Activity

NA

Storage

Storage buffer: 20mM Tris.Cl, 50mM NaCl, 50% Glycerol, pH8.0. Store at -80°C and avoid repeated freeze-thaw cycles.