人视网膜脱氢酶1

Protein Name

Human retinal dehydrogenase 1

Protein Symbol

ALDH1A1

Original Source

Expression System

GenBank Accession #

NM_000689.1

Uniprot Accession #

P00352

Description

This protein belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of the mitochondrial isozyme. This gene encodes a cytosolic isoform, which has a high affinity for aldehydes.

Application

WB, ELISA, IP, antibody production, protein array

Fusion tag

N-His

Peptide Length

516aa(including fusion tag)

Molecular Weight

56.8kDa(including fusion tag)

pI

7.0

Activity

NA

Storage

Storage buffer: 20mM Tris.Cl, 50mM NaCl, 20% Glycerol, pH9.0. Store at -80°C and avoid repeated freeze-thaw cycles.