人腺嘌呤磷酸核糖转移酶

Protein Name

Human adenine phosphoribosyl transferase

Protein Symbol

APRT

Original Source

Expression System

GenBank Accession #

NM_000485.1

Uniprot Accession #

P07741

Description

Adenine phosphoribosyltransferase belongs to purine/pyrimidine phosphoribosyltransferase family. This enzyme catalyzes the formation of AMP and inorganic pyrophosphate from adenine and 5-phosphoribosyl-1-pyrophosphate (PRPP). It also produces adenine as a by-product of the polyamine biosynthesis pathway. A homozygous deficiency in this enzyme causes 2, 8-dihydroxyadenine urolithiasis. Two transcript variants encoding different isoforms have been found for this gene.

Application

WB, ELISA, IP, antibody production, protein array

Fusion tag

N-His

Peptide Length

195aa(including fusion tag)

Molecular Weight

21.5kDa(including fusion tag)

pI

7.0

Activity

NA

Storage

Storage buffer: 20mM Tris.Cl, 50mM NaCl, 50% Glycerol, pH8.0. Store at -80°C and avoid repeated freeze-thaw cycles.