人双功能嘌呤生物合成蛋白PURH

Protein Name

Human bifunctional purine biosynthesis protein PURH

Protein Symbol

ATIC

Original Source

Expression System

GenBank Accession #

D82348.1

Uniprot Accession #

P31939

Description

Bifunctional purine biosynthesis protein PURH is a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity.A mutation in this gene results in AICA-ribosiduria.

Application

WB, ELISA, IP, antibody production, protein array

Fusion tag

N-His

Peptide Length

607aa(including fusion tag)

Molecular Weight

66.5kDa(including fusion tag)

pI

6.9

Activity

NA

Storage

Storage buffer: 20mM Tris.Cl, 50mM NaCl, 50% Glycerol, pH8.0. Store at -80°C and avoid repeated freeze-thaw cycles.