S100 beta Rabbit Monoclonal Antibody

来源

用途

交叉反应性

分子量

Rabbit

WB, IP, IF, IHC, ICC

H, M, R, Z

11.0kDa

WB

IP

IF

IHC

ICC

FC

ELISA

ChIP

1:1,000-1:5,000

1:10-1:50

1:50-1:200

1:50-1:200

1:50-1:200

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-

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About this Antibody

Name

S100 beta Rabbit Monoclonal Antibody

Category

Rabbit Monoclonal Antibody (RabMAb); Primary antibody

Isotype

IgG

Purification

Affinity purification

About the Immunogen

Immunogen

Recombinant protein

Gene ID

6285(Human); 20203(Mouse); 25742(Rat)

SwissProt

P04271(Human); P50114(Mouse); P04631(Rat)

Synonyms

NEF; S100; S100-B; S100beta

Category

Cell Cycle

Background

The family of EF-hand type Ca²⁺-binding proteins includes calbindin (previously designated vitamin D-dependent Ca²⁺-binding protein), S-100 α and β, calgranulins A (also designated MRP8), B (also designated MRP14) and C (S-100 like proteins), and the parvalbumin family members, including parvalbumin α and parvalbumin ∫ (also designated oncomodulin). The S-100 protein is involved in the regulation of cellular processes such as cell cycle progression and differentiation. Research also indicates that the S-100 protein may function in the activation of Ca²⁺ induced Ca²⁺ release, inhibition of microtubule assembly and inhibition of protein kinase C mediated phosphorylation. Two S-100 subunits, sharing 60% sequence identity, have been described as S-100 α chain and S-100 β chain. Three S-100 dimeric forms have been characterized, differing in their subunit composition of either two α chains, two β chains or one α and one β chain. S-100 localizes to the cytoplasm and nuclei of astrocytes, Schwann's cells, ependymomas and astrogliomas. S-100 is also detected in almost all benign naevi, malignant melanocytic tumours and in Langerhans cells in the skin. Calbindin, S-100 proteins and parvalbumin proteins are each expressed in neural tissues. In addition, S-100 α and β are present in a variety of other tissues, and calbindin is present in intestine and kidney.

产品编号

产品名称

包装

AF1945

S100 beta Rabbit Monoclonal Antibody

50μl

AZ050

Western一抗稀释液

50ml

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说明书

1份