Vilazodone (SSRI抑制剂)

化学名

5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl]-1-benzofuran-2-carboxamide

简称

Vilazodone

别名

EMD 68843, SB 659746A, EMD-68843, EMD68843, SB-659746A, SB659746A

中文名

维拉佐酮

化学式

C₂₆H₂₇N₅O₂

分子量

441.52

CAS号

163521-12-8

纯度

98%

溶剂/溶解度

Water<1mg/ml; DMSO5mg/ml; Ethanol<1mg/ml

溶液配制

5mg加入1.13ml DMSO，或者每4.42mg加入1ml DMSO，配制成10mM溶液。SD2452-10mM用DMSO配制。

产品描述

Vilazodone (EMD 68843; SB 659746A) is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression.

信号通路

GPCR & G Protein; Neuronal Signaling

靶点

SSRI

5-HT1A

－

－

－

IC50

－

－

－

－

－

体外研究

Vilazodone represents another option for the treatment of MDD. Vilazodone appears to have a favourable weight-gain profile based on short-term studies. Sexual side-effects were not consistently demonstrated when assessed using clinical rating scales but spontaneously reported AEs related to sexual functioning were observed. Additional controlled data regarding long-term efficacy and effectiveness will help characterise this new agent when used in maintenance treatment.

体内研究

N/A

临床实验

N/A

特征

N/A

酶活性检测实验

方法

N/A

细胞实验

细胞系

N/A

浓度

N/A

处理时间

N/A

方法

N/A

动物实验

动物模型

N/A

配制

N/A

剂量

N/A

给药方式

N/A

产品编号

产品名称

包装

SD2452-10mM

Vilazodone (SSRI抑制剂)

10mM×0.2ml

SD2452-5mg

Vilazodone (SSRI抑制剂)

5mg

SD2452-25mg

Vilazodone (SSRI抑制剂)

25mg

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说明书

1份