Walrycin B (抗菌素)

化学名

1,6-dimethyl-3-[4-(trifluoromethyl)phenyl]pyrimido[5,4-e][1,2,4]triazine-5,7-dione

简称

Walrycin B

别名

Walrycin-B

中文名

N/A

化学式

C₁₄H₁₀F₃N₅O₂

分子量

337.26

CAS号

878419-78-4

纯度

98%

溶剂/溶解度

Water<1mg/ml; DMSO4mg/ml; Ethanol<1mg/ml

溶液配制

5mg加入1.48ml DMSO，或者每3.37mg加入1ml DMSO，配制成10mM溶液。SC3332-10mM用DMSO配制。

产品描述

Walrycin B is a novel antibacterial compound specifically targeting the essential WalR response regulator.

信号通路

Anti-infection

靶点

Antibacterial

－

－

－

－

IC50

－

－

－

－

－

体外研究

Walrycin B is known as an analog of toxoflavin (a phytotoxin from Burkholderia glumae), which has been shown to have a strong MIC for B. subtilis and S. aureus but whose mode of action is not clear. The compound could also interact with WalR to cause bactericidal effects. Walrycins are a new class of potent small molecule compounds that kill bacterial cells by targeting the RR WalR and inhibiting this essential signal transduction pathway. They not only have therapeutic potential but will also prove to be useful reagents for the further study of the WalK/WalR TCS. Walrycin B target WalR and lead to cell death in both B. subtilis and S. aureus.

体内研究

N/A

临床实验

N/A

特征

N/A

酶活性检测实验

方法

N/A

细胞实验

细胞系

N/A

浓度

N/A

处理时间

N/A

方法

N/A

动物实验

动物模型

N/A

配制

N/A

剂量

N/A

给药方式

N/A

产品编号

产品名称

包装

SC3332-10mM

Walrycin B (抗菌素)

10mM×0.2ml

SC3332-5mg

Walrycin B (抗菌素)

5mg

SC3332-25mg

Walrycin B (抗菌素)

25mg

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说明书

1份