哈喹诺，氯化羟基喹啉

哈喹诺是氯化8-羟基喹啉的混合物，作为抗大肠杆菌和沙门氏菌的饲料添加剂，有效成分为5,7-二氯-8-羟基喹啉(57%-74%)、5-氯-8-羟基喹啉(23%-40%)和不超过4%的7-氯-8-羟基喹啉。
　　哈喹诺的抗菌机制是通过与铁、铜和锌等金属离子螯合，阻断酶合成。另外，哈喹诺直接作用在动物肠胃平滑肌，通过降低肠胃蠕动性，提高营养吸收率，对患痢疾的牲畜，疗效特别显著。
　　国外大量实验证明，动物对哈喹诺吸收很少，药物残留问题可以忽略，甚至对产蛋期家禽也无停药期要求，哈喹诺是非常安全的产品，是喹乙醇、卡巴多和喹烯酮的替代产品。

DESCIPTION
Halquinol is a controlled mixture of chlorhydroxyquinolines. The constituents act synergistically to enhance biological activity.
The antimicrobial effects of halquinol derives from its ability to chelate metal ions, particularly iron, copper and zinc. In bacteria, fungi and protozoa, essential trace elements are thus removed, and enzyme functioning ceases.
Additionally, halquinol acts directly on gastrointestinal smooth muscle to slow down peristaltic activity. Thus absorption of nutrients, particularly in animals suffering from diarrhoea, is enhanced, and performance criteria are improved markedly.
Since very little halquinol is absorbed, residues are not a concern and no withholding period is needed, even for laying birds. Halquinol acts entirely in the gut and systemic activity is not necessary. Halquinol is a very safe product.

SPEC.
CAS Registry number: [8067-69-4]
CAS name(s): 5,7-Dichloro-8-quinolinol mixt with 5-chloro-8-quinolinol and 7-chloro-8-quinolinol Additional name(s): chlorquinol ;
Appearance: a yellowish white to yellowish grey powder
Loss on drying: Max.0.5%      Chloride: Max.700 ppm.      Sulphate: Max.700 ppm
5-7 dichloroquinolin-8-ol: 57.0% to 75.0%
5 chloroquinolin-8-ol: 23.0% to 40.0%
7-Chloroquinolin-8-ol: < 4.0%
8-hydroxyquinoline: <0.5%