兔抗TOP2A多克隆抗体

Name

TOP2A Rabbit Polyclonal Antibody

Category

Polyclonal antibody(pAb); Primary antibody

Isotype

IgG

Purification

Peptide affinity purified

Immunogen

This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to TOP2A.

Gene ID

7153

SwissProt

P11388

Synonyms

DNA topoisomerase II; DNA topoisomerase II-alpha; EC 5.99.1.3, P11388-1; TOP-2; TOP2; TOP2A; TP2A; alpha isozyme

Category

Chromatin Regulation / Nuclear Function

Background

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. It is essential during mitosis and meiosis for proper segregation of daughter chromosomes.