N-CADHERIN 兔多克隆抗体

About this Antibody

Name

N-Cadherin Rabbit Polyclonal Antibody

Category

Polyclonal antibody(pAb); Primary antibody

Isotype

IgG

Purification

Peptide affinity purified

About the Immunogen

Immunogen

This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to a region of N-cadherin.

Gene ID

1000

SwissProt

P19022

Synonyms

CDH2; CDCN; NCAD

Category

Adhesion/ECM

Background

The cadherins are a large family of cell adhesion molecules involved in calcium-dependent recognition and adhesion events. The cadherin subfamily includes N-, P-, B-, and E- cadherins, and other members. Recent studies indicate that cancer cells have up-regulated N-cadherin in addition to loss of E-cadherin. N-cadherin cooperates with the FGF receptor, leading to overexpression of MMP-9 and cellular invasion. N-Cadherin is commonly found in cancer cells and provides a mechanism for transendothelial migration. When a cancer cell adheres to the endothelial cells of a blood vessel it up-regulates the src kinase pathway, which phosphorylates beta-catenins attached to both N-cadherin (this protein) and E-cadherins.