兔抗PMS2多克隆抗体

背景资料

PMS1 homolog 2, mismatch repair system component encoded by PMS2 is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. PMS1 homolog 2, mismatch repair system component forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA(X)2E(X)4E motif found at the C-terminus of the protein encoded by PMS2 that forms part of the active site of the nuclease. Mutations in PMS2 have been associated with hereditary nonpolyposis colorectal cancer (HNPCC; also known as Lynch syndrome) and Turcot syndrome.
蛋白别名为：PMS2; PMSL2; Mismatch repair endonuclease PMS2; DNA mismatch repair protein PMS2; PMS1 protein homolog 2;基因ID为：5395；蛋白质ID:P54278

应用类型

WB，IHC-p，IF，ELISA
补充：的抗体稀释比例需要基于客户实验进行优化.建议的起始稀释比例如下: WB: 1:500-1:2000, IHC-p: 1:100-1:300, IF: 1:200-1:1000, ELISA: 1:10000. Not yet tested in other applications.

免疫原

合成多肽：the Internal region of human PMS2. at AA rangle: 430-510

来源宿主

兔

反应性

人

保存建议

厂家推荐蓝冰运输.在发货后能在-20℃保存1年.为限度的避免损失，请在打开管盖之前融化抗体并离心.我们建议使用前分装以避免反复冻融.
本产品为液体形式,溶解于PBS缓冲液中，含50%甘油，0.5%BSA和0.02%NaN3.