磷酸化组蛋白 H2A.X (139位) 兔单克隆抗体

背景资料

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C- terminal phosphorylation.

应用类型

WB

免疫原

P16104

来源宿主

兔

反应性

可识别人、小鼠、大鼠等种属来源样本的Histone H2A.X 蛋白。

保存建议

该抗体2-8°C可保存6个月。长期保存请分装后放于 -20°C ，避免反复冻融。