CASPASE-2 兔单抗

产品编号

产品名称

产品包装

产品价格

AF1123

Caspase-2 Rabbit Monoclonal Antibody

50μl

询价

来源

用途

交叉反应性

分子量

Rabbit

WB, IP, IF, IHC, ICC, FC

H, M, R

48/30/12 kDa

WB

IP

IF

IHC

ICC

FC

ELISA

ChIP

1:1000-1:2000

1:50-1:200

1:50-1:200

1:50-1:200

1:50-1:200

1:50-1:100

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Name

Caspase-2 Rabbit Monoclonal Antibody

Category

Rabbit Monoclonal Antibody (RabMAb); Primary antibody

Isotype

IgG

Purification

Affinity purification

Immunogen

Recombinant protein

Gene ID

835(Human); 12366(Mouse); 64314(Rat)

SwissProt

P42575(Human); P29594(Mouse); P55215(Rat)

Synonyms

ICH1; NEDD2; CASP-2; NEDD-2; PPP1R57

Category

Apoptosis

Background

Caspase-2 (Nedd2, ICH-1) is an aspartate-specific cysteine protease that is activated in response to various apoptotic stimuli. Caspase-2 is unique among the caspases in that it has features of both upstream caspases (long prodomain) and downstream caspases (DEXD substrate specificity). Caspase-2 is highly expressed in the brain during development, and is expressed at low levels in adult tissue. Specifically, caspase-2 localizes to the mitochondria, the Golgi, the cytoplasm, and the nucleus. Caspase-2 exists as two isoforms, caspase-2L and caspase-2S, which are produced by alternative splicing and differ in their N and C-termini. Caspase-2L acts as a positive regulator of apoptosis, whereas caspase-2S functions as a negative regulator of apoptosis. Following apoptotic stimuli, the caspase-2L precursor undergoes cleavage at Asp-153 to produce a fragment (p30). The p30 fragment undergoes further cleavage to generate a fragment containing amino acids 153-308 (p18) and a fragment containing amino acids 317-435 (p13 or p14). As apoptosis progresses, the p13 (p14) fragment can undergo further processing to yield a fragment containing amino acids 331-435 (p12).

产品编号

产品名称

包装

AF1123

Caspase-2 Rabbit Monoclonal Antibody

50μl

AZ050

Western一抗稀释液

50ml

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说明书

1份