RAMAGE 链接剂

Product name: Ramage Linker

Synonym: Fmoc-Suberol,2-[[11-(9H-fluoren-9-ylmethoxycarbonylamino)-6,11-dihydro-5H-dibenzo[1,2-a:1′,3′-e][7]annulen-3-yl]oxy]acetic acid, 5-{[(R,,S)-5-[(9-fluorenylmethoxycarbonyl)aminol-10,l l-dihydrodibenzo[a,dlcyclohepten-2-ylloxy)valeric acid(CHA),

Catalog #: 8511029

Purity: 98%

CAS No.: 212783-75-0

Molecular Formula: C32H27NO5

Molecular Weight: 505.56

Compound ID: 10553577

Description: CHA is a superior handle for routine preparation of peptide amides, which form the stable dibenzotropylium ion during acidolytic cleavage, especially peptides containing acid labile residues such as Trp and/or Tyr(SO3H). CHA handles incorporated into a polymer support can be rapidly cleaved at lower concentrations of TFA than those required for the PAL handle. The half-lives for cleavage with 25% TFA were <4 min for CHA, 35 min for PAL, and 38 min for RAM. The results show that CHA-peptides can be easily and rapidly cleaved to liberate peptides from polymer support using lower TFA concentrations.