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Fmoc-D-His(Bzl)-OH

Fmoc-D-His(Bzl)-OH
500 500MG 起订
上海 更新日期:2022-07-14

燊肽科技(上海)有限公司

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中文名称:
Fmoc-D-His(Bzl)-OH
英文名称:
Fmoc-D-His(Bzl)-OH
CAS号:
2022956-32-5
产品类别:
氨基酸衍生物

Product name: Fmoc-D-His(1-Bzl)-OH

Synonym: Fmoc-D-His(Bzl)-OH, Nalpha-Fmoc-Nim-benzyl-D-histidine, (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1-benzyl-1H-imidazol-4-yl)propanoic acid,

Catalog #: 8217007

Purity: 95%

CAS No.:

Molecular Formula: C28H25N3O4

Molecular Weight: 467.53

Compound ID:

Description: The influence of gonadotrophin-releasing hormone (GnRH) and its analogues (i.e., agonist and antagonist) on vasopressin (VP) release from the rat hypothalamo-neurohypophysial (H-N) system was studied both in vitro and in vivo. Additionally, it was determined whether the possible response of vasopressinergic neurones to these peptides could be modified by melatonin through a cAMP-dependent mechanism. In this study we demonstrate, for the first time, that the highly selective GnRH agonist (i.e., [Des-Gly(10),D-His(Bzl)(6),Pro-NHEt(9)]-LHRH; histrelin) stimulates the release of VP from the rat H-N system, while native GnRH and its antagonist remain inactive in modifying this process in vitro. Melatonin significantly inhibited basal and histrelin-induced release of VP in vitro, but displayed no significant influence on VP secretion when GnRH or its antagonist were present in a medium. Melatonin fully suppressed forskolin-stimulated VP release from the rat H-N system. On the other hand, addition of forskolin to a medium containing both histrelin and melatonin did not further alter the inhibitory influence of melatonin on the histrelin-dependent release of VP in vitro. After intracerebroventricular (i.c.v.) infusion of native GnRH or its agonist, blood plasma VP concentration was significantly higher than in control animals, which was accompanied by decreased content of the hormone in the neurohypophysis. Intravenous (i.v.) injection of melatonin did not change, in any subgroup, blood plasma VP concentration, when compared to the vehicle-injected rats. However, the neurohypophysial levels of the hormone were significantly higher after melatonin injection in control, GnRH- and histrelin-infused animals. Our present results suggest that activation of the GnRH receptor in the hypothalamus is involved in stimulation of VP secretion from the rat H-N system. We have also shown that melatonin, at a concentration close to its physiological level in the blood, significantly reduces the in vitro response of vasopressinergic neurones to a GnRH agonist – histrelin; this effect of melatonin could be mediated through intracellular processes that involve, among others, the cAMP-dependent mechanism.

API: Histrelin

Fmoc-D-His(Bzl)-OH

公司简介

燊肽科技致力于为国内医药研发机构和科研院校提供多肽和氨基酸衍生物相关生化试剂, 以及定制合成技术服务. 我们的产品线包含各种高端进口品牌,以及价格适中的国内自主品牌. 我们保证多肽实验活性和质量, 提供24小时技术支持.A full-service company dedicated to provide qualified peptide related chemicals, proteins and enabling technologies for scientific research. We are serving over 100 customers over North America, Europe , Japan, Korea, Australia Russia, and Latin America. The comprehensive services which assist you on peptides, intermediates manufacturing from the very beginning of pharma research to large

成立日期 (10年)
注册资本 100万
员工人数 1-10人
年营业额 ¥ 300万-500万
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂,技术服务

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