Neladalkib

Neladalkib (NVL-655)

CAS No.: 2739866-40-9 ｜ Catalog-grade: ≥98% (HPLC)

Neladalkib (NVL-655, also referred to as NUV-655 or ALK-IN-27) is a potent, selective, brain-penetrant fourth-generation inhibitor of anaplastic lymphoma kinase (ALK). It was designed to remain active against tumors that have developed resistance to first-, second- and third-generation ALK inhibitors, including those harboring the solvent-front G1202R mutation and compound mutations such as G1202R/L1196M, G1202R/G1269A and G1202R/L1198F. In addition to ALK, Neladalkib shows significant inhibitory activity against ROS1, LTK, PYK2, TRKB and FAK, making it a valuable tool compound for research on ALK-driven malignancies and on overcome-resistance strategies in non-small cell lung cancer (NSCLC).