重组小鼠干扰素γ(IFN-γ)

中文名称：

重组小鼠干扰素γ(IFN-γ)

英文名称：

Mouse IFN-γ protein

品牌：

Abbkine/亚科因

产地：

湖北武汉

保存条件：

建议收到货后避光保存于-20°C，有效期为12个月。

纯度规格：

> 95 % as determined by SDS-PAGE

产品类别：

细胞因子及蛋白 细胞因子

货号：

PRP1961

标签：

无标签

种属：

小鼠

活性：

Measured in a cell proliferation assay using L929. The ED50 for this effect is typically 0.03 ng/mL. The specific activity of recombinant Mouse IFN-γis approximately >3.33 x 107IU/mg.

表达宿主：

大肠杆菌

产品形式：

冻干粉

分子量：

16.9 kDa

运输条件：

冰袋运输（蓝冰）

警告：

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背景：

IFN gamma (IFN-γ), also known as IFNG, is a secreted protein which belongs to the type I I interferon family. IFN gamma is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, and by CD4 and CD8 cytotoxic T lymphocyte effector T cells once antigen-specific immunity develops. IFN-γ has antiviral, immunoregulatory, and anti-tumor properties. IFNG, in addition to having antiviral activity, has important immunoregulatory functions, it is a potent activator of macrophages, and has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. The IFNG monomer consists of a core of six α-helices and an extended unfolded sequence in the C-terminal region. IFN gamma is critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. Aberrant IFN gamma expression is associated with a number of autoinflammatory and autoimmune diseases. The importance of IFN gamma in the immune system stems in part from its ability to inhibit viral replication directly, and most importantly from its immunostimulatory and immunomodulatory effects. IFNG also promotes NK cell activity.

基因ID：

15978

蛋白质ID：

P01580