PROTAC GSK-3β Degrader-11

PROTAC GSK-3β Degrader-1 (CAS No. 3093409-30-1) is a proteolysis-targeting chimera (PROTAC) designed to target glycogen synthase kinase-3 beta (GSK-3β) for targeted protein degradation research. The molecule consists of the GSK-3β inhibitor SB-216763, a polyethylene glycol (PEG) linker, and a cereblon (CRBN) ligand that recruits an E3 ubiquitin ligase.

This compound has been reported to exhibit an IC₅₀ value of 833 nM and to reduce neurotoxicity induced by amyloid-beta Aβ25–35 peptide and copper sulfate (CuSO₄) in experimental studies. It is a useful research compound for investigating targeted protein degradation, GSK-3β-related signaling pathways, and potential therapeutic strategies for Alzheimer's disease.

Specifications: CAS No. 3093409-30-1; molecular formula C₄₃H₄₂Cl₂N₆O₉; molecular weight 857.73 g/mol.

For research use only.