氟比洛芬杂质1

Flurbiprofen Related Impurity 1 (CAS 42771-81-3), chemically diethyl 2-(2-fluoro-[1,1'-biphenyl]-4-yl)-2-methylmalonate (C20H21FO4, MW 344.38), is a malonate-type related substance and synthetic intermediate of the nonsteroidal anti-inflammatory drug flurbiprofen, bearing the 2-fluoro-biphenyl pharmacophore with an α-methylmalonate diester side chain. It is used as a reference standard for the identification and quantification of this compound in flurbiprofen and flurbiprofen axetil APIs and finished formulations, supporting HPLC impurity profiling, method validation, and regulatory quality control.