酮洛芬-13C-d3

Ketoprofen-13C,d3 (CAS 1189508-77-7) is the 13C- and deuterium-labeled analog of the nonsteroidal anti-inflammatory drug ketoprofen (RP-19583), in which the methyl group of the propionic acid side chain is replaced by a 13C-labeled trideuteromethyl group (C15¹³CH11D3O3, MW 258.29). Ketoprofen is a potent inhibitor of cyclooxygenase (COX), with IC50 values of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively. Ketoprofen-13C,d3 is intended for use as a stable-isotope-labeled internal standard for the quantitative determination of ketoprofen by NMR, GC-MS, or LC-MS, supporting pharmacokinetic, bioanalytical, and drug development studies.