Thalidomide-Piperazine-PEG2-NH2

Thalidomide-Piperazine-PEG2-NH₂ is a synthesized E3 ubiquitin ligase ligand-linker conjugate containing a thalidomide-derived cereblon (CRBN) ligand , a piperazine moiety, and a PEG2 linker with a terminal amine group. It can be used as a PROTAC/targeted protein degradation (TPD) building block for recruiting the CRBN E3 ubiquitin ligase in the design and synthesis of heterobifunctional protein degraders. The terminal amine provides a reactive site for further coupling with carboxylic acids, activated esters, or other compatible functional groups.

• CAS No.: 2357110-14-4

• Formula: C₂₃H₃₁N₅O₆

• Molecular Weight: 473.52 g/mol

For research use only. Not for human or clinical use.