TL12-186

TL12-186 is a multi-kinase PROTAC degrader that recruits the cereblon (CRBN) E3 ubiquitin ligase to induce targeted degradation of multiple kinases. TL12-186 targets a broad range of kinases, including FLT3, BTK, AURKA, PTK2B, and cyclin-dependent kinases (CDKs) , through the ubiquitin-proteasome system.

By promoting targeted kinase degradation, TL12-186 can be used as a research tool for investigating kinase signaling, targeted protein degradation, and kinase-dependent cellular processes . TL12-186 is particularly applicable to studies of leukemia and cancer biology , as well as research into PROTAC-mediated multi-target protein degradation.

CAS No.: 2250025-88-6
Molecular Formula: C₄₄H₅₁ClN₁₀O₉S
Molecular Weight: 931.46 g/mol