CDK9 degrader-2

CDK9 degrader-2 (CAS No. 3020773-81-0) is a synthetic autophagosome-tethering compound (ATTEC) designed to induce degradation of the CDK9/Cyclin T1 protein complex through the autophagy–lysosome pathway. Unlike conventional PROTACs, it operates independently of the ubiquitin–proteasome system by simultaneously engaging CDK9 and LC3B , promoting recruitment of the target complex to autophagosomes for lysosomal degradation.

CDK9 degrader-2 is reported to downregulate Mcl-1 and c-Myc , induce apoptosis, and show antitumor activity in an MV4-11 xenograft model , making it useful for research on targeted protein degradation and leukemia biology.

CAS No.: 3020773-81-0
Molecular Formula: C₃₂H₄₀N₄O₆S₂
Molecular Weight: 640.81 g/mol
Product Type: ATTEC / autophagic protein degrader
Target: CDK9/Cyclin T1
Degradation Pathway: Autophagy–lysosome pathway
Key Features: CDK9-targeting ligand, linker, LC3B-recruiting moiety

Applications: Targeted protein degradation, autophagy research, CDK9/Cyclin T1 research, leukemia research, cancer biology, and chemical biology.