PDEδ autophagic degrader 1

PDEδ autophagic degrader 1 (CAS No. 3054112-59-0) is a synthetic autophagosome-tethering compound (ATTEC) designed to induce the selective degradation of PDEδ (phosphodiesterase δ) through the autophagy–lysosome pathway. The molecule contains a PDEδ-targeting ligand, a linker region, and an LC3-binding component , enabling recruitment of the target protein to autophagosomes for subsequent lysosomal degradation.

This small-molecule degrader is useful for studying PDEδ degradation, autophagy-mediated protein clearance, KRAS-related signaling, targeted protein degradation, and chemical biology .

CAS No.: 3054112-59-0
Molecular Formula: C₄₁H₄₂Br₂IN₇O₅
Molecular Weight: 999.53 g/mol
Product Type: ATTEC / autophagic protein degrader
Target: PDEδ
Degradation Pathway: Autophagy–lysosome pathway
Applications: Targeted protein degradation, autophagy research, PDEδ research, KRAS-related cancer research, and chemical biology.