AUTAC4

AUTAC4 is a synthetic mitochondria-targeting autophagy-targeting chimera (AUTAC) designed to promote selective mitochondrial turnover through mitophagy . It is a multifunctional small molecule containing a guanine-derived AUTAC moiety, a mitochondrial-targeting component, and a flexible polyether linker that connects the functional regions.

AUTAC4 promotes K63-linked polyubiquitination and facilitates the autophagic clearance of dysfunctional or fragmented mitochondria, providing a chemical approach for studying mitochondrial quality control and targeted autophagic degradation. In cellular research, AUTAC4 has been reported to induce mitophagy and help restore mitochondrial function following mitochondrial injury.

CAS No.: 2267315-04-6
Molecular Formula: C₄₃H₄₈FN₉O₈S
Molecular Weight: 869.96 g/mol
Product Type: Mitochondria-targeting autophagy-targeting chimera (AUTAC)
Target/Process: Mitochondria / Mitophagy
Degradation Pathway: Autophagy–lysosome pathway

AUTAC4 is useful as a research tool for targeted mitochondrial degradation, mitophagy, autophagy, mitochondrial quality control, mitochondrial turnover, and chemical biology studies .