HaloAUTAC tt15 (Halo PROTAC 1)

HaloAUTAC tt15 (also known as Halo PROTAC 1 ) is a synthetic small-molecule autophagy-targeting chimera (AUTAC) designed for targeted degradation of HaloTag-carrying proteins . The compound contains a HaloTag-reactive chloroalkyl moiety, an AUTAC functional region, and a flexible polyether linker that connects the two functional components.

HaloAUTAC tt15 promotes degradation of HaloTag-fused target proteins through an autophagy/lysosomal degradation pathway , providing an alternative to conventional PROTACs that primarily utilize the ubiquitin–proteasome system. In cell-based research, HaloAUTAC tt15 has been reported to induce degradation of EGFP-HaloTag fusion protein in HeLa cells.

CAS No.: 2241668-45-9
Molecular Formula: C₃₃H₄₉Cl₂N₇O₈S
Molecular Weight: 774.76 g/mol
Product Type: Autophagy-targeting chimera (AUTAC) / Targeted Protein Degradation (TPD) compound
Target: HaloTag fusion proteins
Degradation Pathway: Autophagy–lysosome pathway

HaloAUTAC tt15 is useful as a chemical biology research tool for studying targeted autophagic protein degradation, HaloTag-based protein regulation induced proximity, autophagy, lysosomal degradation, and targeted protein degradation . Its modular linker-containing structure also provides a useful reference for the design and synthesis of AUTAC degraders and functional degrader conjugates .