一、产品概述
ACPA 是来自R&D Systems品牌的高品质产品，适用于科研实验领域。
更多产品描述请查看优宁维官网(https://www.univ-bio.com/human-proteinase-3myeloblastinprtn3/MAB61341-SP.html?mk_channel=chemicalbook)
二、产品信息
| 货号 | MAB61341 |
| SKU货号 | MAB61341 |
| 品牌 | R&D Systems |
| 中文名称 | ACPA |
| 英文名称 | Arachidonoyl Cyclopropylamide |
| 抗原名称 | ACPA， AGP7， AGP7PR3， azurophil granule protein 7， C-ANCA， EC 3.4.21， EC 3.4.21.76， Leukocyte protein |
| 宿主 | Mouse IgG2b |
| 克隆号 | 684022 |
| 荧光素标记 | Unconjugated |
| 研究领域 | Related Research Areas- Airway Inflammation and Remodeling
- Inflammatory Mediators
- Neutrophils
- Serine Proteases and Regulators
|
三、背景
| 别名 | ACPA,AGP7,AGP7PR3,azurophil granule protein 7,C-ANCA,EC 3.4.21,EC 3.4.21.76,Leukocyte proteinase 3,MBN,MBT,Myeloblastin,Neutrophil proteinase 4,NP4,NP-4,P29C-ANCA antigen,PR-3CANCA,Proteinase 3,PRTN3,serine proteinase, neutrophil,Wegener autoantigen,Wegener granulomatosis autoantigen |
| 研究领域 | Related Research Areas- Airway Inflammation and Remodeling
- Inflammatory Mediators
- Neutrophils
- Serine Proteases and Regulators
|
背景
Background: Proteinase 3/Myeloblastin/PRTN3
Leukocyte proteinase 3 (PRTN3 or PR3), also called Myeloblastin (MBN) or NP-4, is a 32-33 kDa member of the peptidase S1 family of enzymes. It is expressed by monocytes and neutrophils, the latter of which either secretes it, sequesters it in azurophilic granules, or expresses it on the cell surface. When secreted, it acts on HK and activates the kinin pathway. In azurophilic granules, it aids in the digestion of phagocytosed material. On the cell surface, it likely acts on ECM. Human MBN proprecursor is 231 amino acids (aa) in length. It contains an Ala26Glu27 propeptide that is removed during maturation, a 221 aa mature enzyme (aa 28-248), and an eight aa C-terminal propeptide (aa 249-256). Within the cell, a 35 kDa immature form exists; on the cell surface, both constitutively inactive, and induced active forms may be found, often in a noncovalent association with CD177/NB1. Over aa 26-249, human MBN shares 68% aa sequence identity with mouse MBN.
Entrez Gene IDs
5657 (Human); 19152 (Mouse); 314615 (Rat)
Alternate Names
ACPA; AGP7; AGP7PR3; azurophil granule protein 7; C-ANCA; EC 3.4.21; EC 3.4.21.76; Leukocyte proteinase 3; MBN; MBT; Myeloblastin; Neutrophil proteinase 4; NP4; NP-4; P29C-ANCA antigen; PR-3CANCA; Proteinase 3; PRTN3; serine proteinase, neutrophil; Wegener autoantigen; Wegener granulomatosis autoantigen
四、制备和贮存
| 保存方式 | Preparation and StorageReconstitution Sterile PBS to a final concentration of 0.5 mg/mL. Shipping Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below. Stability & Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles. - 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
|
| 溶解方法 | Sterile PBS to a final concentration of 0.5 mg/mL. |
五、应用
| 实验应用 | Immunocytochemistry(8-25 µg/mL)
|
六、产品特点
- 品质保证：经过严格的质量控制，确保产品的高品质和稳定性。
七、注意事项
- 本产品仅供科学研究使用，不可用于临床诊断或治疗。
- 请在通风良好的环境下操作，佩戴适当的个人防护装备。
- 如不慎接触皮肤或眼睛，请立即用大量清水冲洗并就医。
ACPA; AGP7; AGP7PR3; azurophil granule protein 7; C-ANCA; EC 3.4.21; EC 3.4.21.76; Leukocyte proteinase 3; MBN; MBT; Myeloblastin; Neutrophil proteinase 4; NP4; NP-4; P29C-ANCA antigen; PR-3CANCA; proteinase 3; PRTN3; serine proteinase, neutrophil; Wegener autoantigen; Wegener granulomatosis autoantigen,ACPA， AGP7， AGP7PR3， azurophil granule protein 7， C-ANCA， EC 3.4.21， EC 3.4.21.76， Leukocyte proteinase 3， MBN， MBT， Myeloblastin， Neutrophil proteinase 4， NP4， NP-4， P29C-ANCA antigen， PR-3CANCA， Proteinase 3， PRTN3， serine proteinase, neutrophil， Wegene
