2,5-DIMETHYL-4-[2-(PHENYLMETHYL)BENZOYL]-1H-PYRROLE-3-CARBOXYLIC ACID METHYL ESTER-F-160

一、产品概述

二、产品信息

An Opener of L-type Ca2+ Channels;FPL 64176 (#F-160) is a highly pure, synthetic, and biologically active compound.

三、背景

FPL 64176 acts as a non-dihydropyridine L-type calcium channel activator with high efficacy properties. It's a benzoylpyrrole compound that has the ability to increase macroscopic inward current through L-type calcium channels. It extends the opening of single calcium channels during depolarization and slows channel closing upon repolarization without affecting currents through other calcium channels1-3.
FPL 64176 is being used as a tool for studying the physiological roles and disorders of L-type channels, identification of L-type currents within the mix of channel subtypes and for increasing the contractility of smooth and cardiac muscle2.
The use of FPL 64176 has revealed an inactivation and adaptation process for ryanodine receptors and the presence of cardiac sparklets3,4.
L-type voltage-gated calcium channels are one of the three major classes (CaV1-CaV3) of voltage-gated calcium channels. They are expressed in many excitable tissues and play as important transducers in the plasma membrane, altering membrane depolarization to intracellular signaling. Many physiological functions, including brain, endocrine, and sensory functions and muscle contraction rely on proper L-type channel activity5.

四、制备和贮存

五、产品特点

六、注意事项