4-(5,6-dimethoxybenzo[b]thiophen-2-yl)-4-oxobutanoic acid (MSA-2)

Product Name: MSA-2

Chemical Name: 4-(5,6-Dimethoxybenzo[b]thiophen-2-yl)-4-oxobutanoic acid

Chemical Formula: C₁₄H₁₄O₅S
Molecular Weight: 294.32 g/mol

Product Description:

MSA-2 is a small-molecule STING (stimulator of interferon genes) agonist used as a research tool for investigating the cGAS-STING innate immune signaling pathway. MSA-2 is a non-cyclic dinucleotide STING agonist and can be used to study STING activation and downstream immune signaling.

By activating the STING pathway, MSA-2 can be investigated in research involving type I interferon signaling, innate immune activation, inflammatory responses, tumor immunology, and cancer immunotherapy . STING activation has been widely studied for its role in regulating antitumor immune responses and interactions within the tumor microenvironment.

MSA-2 is particularly useful for in vitro and in vivo research involving STING signaling, immune-cell activation, cytokine responses, tumor microenvironment modulation, and combination strategies with other immunotherapeutic approaches.

Product Type: Small-molecule STING agonist
Target: STING (Stimulator of Interferon Genes)
Pathway: cGAS-STING signaling pathway
Mechanism: STING activation / innate immune signaling
Formula: C₁₄H₁₄O₅S
Molecular Weight: 294.32 g/mol
Applications: STING pathway research, innate immunity, tumor immunology, cancer immunotherapy research, tumor microenvironment studies, interferon signaling, immune activation, and drug-development research.