组织蛋白酶 K多肽；Cathepsin K substrate/221055-89-6/Abz-HPGGPQ-EDDnp

Product Name：Abz-HPGGPQ-EDDnp

CAS No.：221055-89-6

Synonyms：组织蛋白酶 K多肽；Cathepsin K substrate

Catalog No.：218P588

Brand：Typeptide Biotech（肽研生物）

Description：Abz-HPGGPQ-EDDnp是一种有生物活性的肽，序列中含有6个氨基酸。组织蛋白酶是一类球状溶酶体蛋白酶，在哺乳动物细胞更新中发挥着至关重要的作用。它们降解多肽并以其底物特异性来区分。组织蛋白酶 K 是参与骨重塑和骨吸收的溶酶体半胱氨酸蛋白酶。它具有作为自身免疫性疾病和骨质疏松症药物靶点的潜力。这种 FRET 肽可用于选择性监测生理液和细胞裂解物中的组织蛋白酶 K 活性。 Abz-HPGGPQ-EDDnp是最初为锥虫酶开发的底物，可被组织蛋白酶 K 在 Gly-Gly 键处有效裂解。该肽可抵抗组织蛋白酶 B、F、H、L、S 和 V 的水解，Ex/Em=340 nm/420 nm。)

Abz HPGGPQ-EDDnp is a biologically active peptide containing 6 amino acids in its sequence. Proteases are a class of spherical lysosomal proteases that play a crucial role in mammalian cell renewal. They degrade peptides and distinguish them based on their substrate specificity. Cathepsin K is a lysosomal cysteine protease involved in bone remodeling and resorption. It has the potential to serve as a drug target for autoimmune diseases and osteoporosis. This FRET peptide can be used for selective monitoring of tissue protease K activity in physiological fluids and cell lysates. Abz HPGGPQ-EDDnp is a substrate originally developed for trypanosomes, which can be effectively cleaved by protease K at the Gly Gly bond. This peptide can resist the hydrolysis of proteases B, F, H, L, S, and V, Ex/Em=340 nm/420 nm。)

Purity (HPLC) ≥98.0%

Single impurity≤2%

Peptide content≥75.0%

Amino Acid Composition≤±15%

Bacterial Endotoxins≤50EU/mg

Solubility：H₂O/DMSO

Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.

Storage:Cool dry place( Store at -20°C, away from the light)

Remark:For Research Use Only. Not for human use.

订购联系方式：

南京肽研生物生物科技有限公司

手机号：19961912513(微信同号)

QQ: 2178255659

邮箱：sales@typeptide.com

联系人：顾经理

申明：本产品仅供科研使用，不得用于人体。