(2-氟-4-甲烷磺酰基-苯基)-{6-[4-(3-异丙基-[1,2,4]噁二唑-5-基)-哌啶-1-基]-5-硝基嘧啶-4-基}-胺

N-(2-Fluoro-4-(methylsulfonyl)phenyl)-6-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)-5-nitropyrimidin-4-amine

询价 25kg/桶起订

陕西更新日期：2026-09-10

陕西西化化学工业有限公司

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产品详情:

中文名称：: (2-氟-4-甲烷磺酰基-苯基)-{6-[4-(3-异丙基-[1,2,4]噁二唑-5-基)-哌啶-1-基]-5-硝基嘧啶-4-基}-胺

英文名称：: N-(2-Fluoro-4-(methylsulfonyl)phenyl)-6-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)-5-nitropyrimidin-4-amine

CAS号：: 733750-99-7

品牌：: 缔都

纯度规格：: 98%

产品类别：: 中间体

级别：: 医药级

分子式：: C21H24FN7O5S

业务负责人：: 负责人：汪经理：17392713612微信同号，QQ：1655706449

中文名	(2-氟-4-甲烷磺酰基-苯基)-{6-[4-(3-异丙基-[1,2,4]噁二唑-5-基)-哌啶-1-基]-5-硝基嘧啶-4-基}-胺
英文名	N-(2-fluoro-4-methylsulfonylphenyl)-5-nitro-6-[4-(3-propan-2-yl-1,2,4-oxadiazol-5-yl)piperidin-1-yl]pyrimidin-4-amine
英文别名	更多

描述	AR231453是GPR119激动剂,能增强葡萄糖依赖的胰岛素分泌和GLP-1释放。
相关类别	信号通路 >> G 蛋白偶联受体/G 蛋白 >> GPR119 研究领域 >> 代谢疾病
参考文献	[1]. Chu ZL, et al. A role for beta-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release. Endocrinology. 2007 Jun;148(6):2601-9. [2]. Chu ZL, et al. A role for intestinal endocrine cell-expressed g protein-coupled receptor 119 in glycemic control by enhancing glucagon-like Peptide-1 and glucose-dependent insulinotropic Peptide release. Endocrinology. 2008 May;149(5):2038-47. [3]. Semple G, et al. Discovery of the first potent and orally efficacious agonist of the orphan G-protein coupled receptor 119. J Med Chem. 2008 Sep 11;51(17):5172-5.

描述

AR231453是GPR119激动剂,能增强葡萄糖依赖的胰岛素分泌和GLP-1释放。

相关类别

信号通路 >> G 蛋白偶联受体/G 蛋白 >> GPR119

研究领域 >> 代谢疾病

参考文献

[1]. Chu ZL, et al. A role for beta-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release. Endocrinology. 2007 Jun;148(6):2601-9.

[2]. Chu ZL, et al. A role for intestinal endocrine cell-expressed g protein-coupled receptor 119 in glycemic control by enhancing glucagon-like Peptide-1 and glucose-dependent insulinotropic Peptide release. Endocrinology. 2008 May;149(5):2038-47.

[3]. Semple G, et al. Discovery of the first potent and orally efficacious agonist of the orphan G-protein coupled receptor 119. J Med Chem. 2008 Sep 11;51(17):5172-5.

分子式	C21H24FN7O5S
分子量	505.52300
精确质量	505.15400
PSA	168.31000
LogP	5.30340
InChIKey	DGBKNTVAKIFYNU-UHFFFAOYSA-N
SMILES	CC(C)c1noc(C2CCN(c3ncnc(Nc4ccc(S(C)(=O)=O)cc4F)c3[N+](=O)[O-])CC2)n1